Missouri Nurse Practitioner License Requirements
Complete guide to becoming a Nurse Practitioner in Missouri
Reduced practice authority with some limitations
Prescriptive Authority: Collaborative Practice Agreement required; Schedule III-V only
1 Education Requirements
Degree Required
Master of Science in Nursing (MSN) or Doctor of Nursing Practice (DNP)
Program Requirements
- Complete accredited Nurse Practitioner program
- Hold active RN license in the state
- Clinical hours as specified by program
2 National Certification
Certification Body
ANCC or AANPCB
Required
Yes
American Nurses Credentialing Center or American Academy of Nurse Practitioners Certification Board
3 Background Check
4 Fees
Initial Licensure
| Application Fee | $150 |
| Total | $150 |
Missouri issues Document of Recognition rather than separate APRN license
Renewal
| Renewal Fee (every 2 years) | $0 |
Prerequisites
To become a Nurse Practitioner in Missouri, you must first hold an active RN license. Missouri is a member of the Nurse Licensure Compact (NLC), so you may hold a multistate RN license.
State Board of Nursing
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Other APRN Types in Missouri
NLC Compact Member
Missouri is a member of the Nurse Licensure Compact for RN/LPN licenses.
Learn about NLC benefits →Clinically reviewed by Clinical Review Team
Based on 1 official sources • Last verified: January 2026