NP Prescriptive Authority by State
28 states let nurse practitioners prescribe independently. The other 22 require a collaborative agreement with a physician.
Key points
- 28 independent prescribing states, all with full practice authority.
- 22 collaborative states: 11 with reduced practice and 11 with restricted practice.
- Every NP who prescribes controlled substances needs a DEA registration in each state where they practice.
- The MATE Act requires a one-time 8-hour substance use disorder training attestation at your first DEA registration or renewal after June 27, 2023.
Prescribing rules in all 50 states
Practice and prescribing status from each state board, last audited July 2026. Select a state for fees, certification, and renewal rules.
Frequently asked questions
In how many states can nurse practitioners prescribe independently?
28 states let nurse practitioners prescribe without a physician agreement. The other 22 require a collaborative or supervisory agreement with a physician for some or all prescribing.
Do nurse practitioners need a DEA registration?
Yes, to prescribe controlled substances. The DEA treats NPs as mid-level practitioners, and the registration only covers what the state where you practice allows. You need a separate DEA registration for each state you practice in.
What is the MATE Act training requirement for NPs?
Since June 27, 2023, every practitioner applying for or renewing a DEA registration must attest once to 8 hours of training on substance use disorders. Graduating in the past 5 years from an accredited advanced practice nursing program that included that training also counts.
Does full practice authority mean an NP can prescribe controlled substances?
Not automatically. Full practice states let NPs prescribe without a physician agreement, but schedules, quantity limits, and any separate state controlled-substance registration are set by each state. Check your state board before you prescribe.